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Hox11 paralo- gous genes are essential for metanephric kidney induction. 2 Physical features (variable) Flat facial profile Characteristic features of Down syndrome Neurobehavioral features (variable) Early development Intellectual speech impairment Hypotonia-motor delay Infantile seizures Childhood Inattention-hyperactivity Aggressivedisruptive behaviors Stereotypiesautistic features Unusual sensory preferences-responding Adolescence and adulthood Depression Anxiety Obsessivecompulsive features Late adulthood Alzheimer-type pathology and dementia Seizures Parkinsonian features Poor primitive and deep tendon reflexes Hypotonia Hyperlaxity of joints Excessive skin on neck Slanted palpebral fissures Pelvic dysplasia Anomalous auricles Dysplastic midphalanx 5th finger Single palmar crease Adolescence and adulthood Down syndrome newborns demonstrating more than four features (100) Down syndrome newborns demonstrating more than six features (90) From: Adapted from Roizen NJ, Patterson D.

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