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2 Milestone Events 169 First Human MHC Class II-bound Self-peptides: Hydrophobic Motifs To the astonishment of experts in this field, the first naturally processed peptides identified from class II MHC molecules did not display an apparent anchor motif, which was one of the hallmarks of both murine and human MHC class I-asso- ciated self-peptides.
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Control of Trdaing Movement 335 Highest level Sensorimotor cortex Thalamus Motor neurons (final common pathway) Basal ganglia Brainstem Cerebellum Local level (brainstem and spinal cord) Afferent neurons Motor control hierarchy Highest level Middle level Local level Receptors Muscle fibers FIGURE 121 The conceptual hierarchical organization of the neural systems controlling body movement.
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